Kasper Laboratory
What We Do
The focus of the Kasper laboratory is on the centrality of the microbiome in immune system development, maturation, and regulation. The laboratory’s research defines the phylogenetic diversity, immune mechanisms, and immunomodulatory therapeutic potential of bacteria and bacterial molecules in autoimmune and infectious diseases. We also investigate the chemistry and immunology of bacterial polysaccharides and lipids, gaining fundamental insights into their role in pathogenesis, as protective vaccine antigens, and as critical modulators of mucosal and systemic immunity.
Selected Recent Publications
2024
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C Macbeth, Elyza A Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M Chiu, Jeffrey R Moffitt, Ansel Hsiao, John J Mekalanos, Christophe Benoist, and Dennis L Kasper. 2024. “Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals.”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036
Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C Macbeth, Elyza A Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M Chiu, Jeffrey R Moffitt, Ansel Hsiao, John J Mekalanos, Christophe Benoist, and Dennis L Kasper. 2024. “Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals.”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036
2023
2023. “Targeting PD-L2-RGMG Overcomes Microbiome-Related Immunotherapy Resistance.”. Nature, 617, Pp. 377-85
2023. “Targeting PD-L2-RGMG Overcomes Microbiome-Related Immunotherapy Resistance.”. Nature, 617, Pp. 377-85
2020
Deepshika Ramanan, Esen Sefik, Silvia Galvin-Pena, Meng Wu, Liang Yang, Zhen Yang, Aleksandar Kostic, Tatyana Golovkina, Dennis Kasper, Diane Mathis, and Christophe Benoist. 2020. “An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint”. Cell, 181, 6, Pp. 1276-90
Deepshika Ramanan, Esen Sefik, Silvia Galvin-Pena, Meng Wu, Liang Yang, Zhen Yang, Aleksandar Kostic, Tatyana Golovkina, Dennis Kasper, Diane Mathis, and Christophe Benoist. 2020. “An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint”. Cell, 181, 6, Pp. 1276-90