@article {1364629, title = {An immunologic mode of multigenerational transmission governs a gut Treg setpoint}, journal = {Cell}, volume = {181}, year = {2020}, pages = {1276-1290.}, abstract = {

At the species level, immunity depends on the selection and transmission of protective components of the\ immune system. A microbe-induced population of RORg -expressing regulatory T cells (Tregs) is essential\ in controlling gut inflammation. We uncovered a non-genetic, non-epigenetic, non-microbial mode of transmission\ of their homeostatic setpoint. RORg+\ Treg proportions varied between inbred mouse strains, a trait\ transmitted by the mother during a tight age window after birth but stable for life, resistant to many microbial\ or cellular perturbations, then further transferred by females for multiple generations. RORg+\ Treg proportions\ negatively correlated with IgA production and coating of gut commensals, traits also subject to\ maternal transmission, in an immunoglobulin- and RORg+\ Treg-dependent manner. We propose a model\ based on a double-negative feedback loop, vertically transmitted via the entero-mammary axis. This immunologicmode\ of multi-generational transmission may provide adaptability and modulate the genetic tuning of\ gut immune responses and inflammatory disease susceptibility.

}, author = {Ramanan, Deepshika and Sefik, Esen and Galvin-Pena, Silvia and Wu, Meng and Yang, Liang and Yang, Zhen and Kostic, Aleksandar and Golovkina, Tatyana and Kasper, Dennis L and Mathis, Diane and Benoist, Christophe} }