@article {1155045,
	title = {How colonization by microbiota in early life shapes the immune system},
	journal = {Science},
	volume = {352},
	year = {2016},
	month = {2016 Apr 29},
	pages = {539-44},
	abstract = {Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental exposures or contributing to the development of disease in later life, including inflammatory bowel disease, allergy, and asthma. Recent studies have begun to define a critical period during early development in which disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets. Here, we discuss the role of early-life education of the immune system during this "window of opportunity," when microbial colonization has a potentially critical impact on human health and disease.},
	keywords = {Age Factors, Asthma, Humans, Hypersensitivity, Immune System, Immune Tolerance, Infant, Newborn, Inflammatory Bowel Diseases, Intestinal Mucosa, microbiota, Natural Killer T-Cells, symbiosis, T-Lymphocyte Subsets},
	author = {Gensollen, Thomas and Iyer, Shankar S and Kasper, Dennis L and Blumberg, Richard S}
}
