@article {1155043,
	title = {Mining the Human Gut Microbiota for Immunomodulatory Organisms},
	journal = {Cell},
	volume = {168},
	year = {2017},
	month = {2017 Feb 23},
	pages = {928-943.e11},
	abstract = {Within the human gut reside diverse microbes coexisting with the host in a mutually advantageous relationship. Evidence has revealed the pivotal role of the gut microbiota in shaping the immune system. To date, only a few of these microbes have been shown to modulate specific immune parameters. Herein, we broadly identify the immunomodulatory effects of phylogenetically diverse human gut microbes. We monocolonized mice with each of 53 individual bacterial species and systematically analyzed host immunologic adaptation to colonization. Most microbes exerted several specialized, complementary, and redundant transcriptional and immunomodulatory effects. Surprisingly, these were independent of microbial phylogeny. Microbial diversity in the gut ensures robustness of the microbiota{\textquoteright}s ability to generate a consistent immunomodulatory impact, serving as a highly important epigenetic system. This study provides a foundation for investigation of gut microbiota-host mutualism, highlighting key players that could identify important therapeutics.},
	keywords = {Adaptive Immunity, Animals, Bacteria, Bacterial Physiological Phenomena, Gastrointestinal Microbiome, Gastrointestinal Tract, Germ-Free Life, Humans, Immunity, Innate, Mice, Mice, Inbred C57BL, symbiosis},
	author = {Geva-Zatorsky, Naama and Sefik, Esen and Kua, Lindsay and Pasman, Lesley and Tan, Tze Guan and Ortiz-Lopez, Adriana and Yanortsang, Tsering Bakto and Yang, Liang and Jupp, Ray and Mathis, Diane and Benoist, Christophe and Kasper, Dennis L}
}
