# Selected Recent Publications Selected Papers from over 450 Publications ## Publications Complete listing of original publications click [here](https://www.ncbi.nlm.nih.gov/pubmed/?term=kasper%20dl). [Google Scholar Citations](https://scholar.google.com/citations?hl=en&user=B4a4828AAAAJ). Download 51 citations download- [BibTeX](/bibcite/export?pager_style=standard_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=standard_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=standard_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=standard_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=tagged) - [Marc](/bibcite/export?pager_style=standard_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=marc) - [PubMedId](/bibcite/export?pager_style=standard_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=standard_pager&number_of_items=20&sort_field=bibcite_year--desc&taxonomy_filters=&&&format=ris) ### 2024 Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C Macbeth, Elyza A Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M Chiu, Jeffrey R Moffitt, Ansel Hsiao, John J Mekalanos, Christophe Benoist, and Dennis L Kasper. 2024. “[Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals.](/publication/gut-complement-induced-microbiota-combats-pathogens-and-spares-commensals)”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036 Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C Macbeth, Elyza A Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M Chiu, Jeffrey R Moffitt, Ansel Hsiao, John J Mekalanos, Christophe Benoist, and Dennis L Kasper. 2024. “[Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals.](/publication/gut-complement-induced-microbiota-combats-pathogens-and-spares-commensals)”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036 - add\_circle do\_not\_disturb\_on Abstract Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a functioning complement system on intestinal mucosal surfaces. Herein, we report the local synthesis of... ### 2023 2023. “[Targeting PD-L2-RGMG Overcomes Microbiome-Related Immunotherapy Resistance.](/publications/targeting-pd-l2-rgmg-overcomes-microbiome-related-immunotherapy-resistance)”. Nature, 617, Pp. 377-85 2023. “[Targeting PD-L2-RGMG Overcomes Microbiome-Related Immunotherapy Resistance.](/publications/targeting-pd-l2-rgmg-overcomes-microbiome-related-immunotherapy-resistance)”. Nature, 617, Pp. 377-85 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://doi.org/10.1038/s41586-023-06026-3) - [ picture\_as\_pdftargeting\_pd-l2-rgmb\_over...](/sites/g/files/omnuum3561/files/kasperlab/files/targeting_pd-l2-rgmb_overcomes_microbiome-related_immunotherapy_resistance_-_s41586-023-06026-3.pdf.pdf) - [ descriptionPublisher's Version](https://doi.org/10.1038/s41586-023-06026-3) - [ picture\_as\_pdftargeting\_pd-l2-rgmb\_over...](/sites/g/files/omnuum3561/files/kasperlab/files/targeting_pd-l2-rgmb_overcomes_microbiome-related_immunotherapy_resistance_-_s41586-023-06026-3.pdf.pdf) ### 2020 Xinyang Song, Ximei Sun, Sungwang Oh, Yanbo Zhang, Wen Zheng, Naama Geva-Zatorsky, Ray Jupp, Diane Mathis, Christophe Benoist, and Dennis L. Kasper. 2020. “[Microbial Bile Acid Metabolites Modulate Gut RORγ +Regulatory T Cellhomeostasis.](/publications/microbial-bile-acid-metabolites-modulate-gut-ror%CE%B3-regulatory-t)”. Nature, 577, 7790, Pp. 410-15 Xinyang Song, Ximei Sun, Sungwang Oh, Yanbo Zhang, Wen Zheng, Naama Geva-Zatorsky, Ray Jupp, Diane Mathis, Christophe Benoist, and Dennis L. Kasper. 2020. “[Microbial Bile Acid Metabolites Modulate Gut RORγ +Regulatory T Cellhomeostasis.](/publications/microbial-bile-acid-metabolites-modulate-gut-ror%CE%B3-regulatory-t)”. Nature, 577, 7790, Pp. 410-15 - add\_circle do\_not\_disturb\_on Abstract The metabolic pathways encoded by the human gut microbiome constantly interact with host gene products through numerous bioactive molecules1. Primary bile acids (BAs) are synthesized within hepatocytes and released into the duodenum to facilitate... Wen Zheng, Wenjing Zhao, Meng Wu, Xinyang Song, Florence Caro, Ximei Sun, Francesca Gazzaniga, Giuseppe Stefanetti, Sungwhan Oh, John Mekalanos, and Dennis Kasper. 2020. “[Microbiota-Targeted Maternal Antibodies Protect Neonates from Enteric Infection](/publications/microbiota-targeted-maternal-antibodies-protect-neonates-enteric-infection)”. Nature, 577, 7791, Pp. 543-48 Wen Zheng, Wenjing Zhao, Meng Wu, Xinyang Song, Florence Caro, Ximei Sun, Francesca Gazzaniga, Giuseppe Stefanetti, Sungwhan Oh, John Mekalanos, and Dennis Kasper. 2020. “[Microbiota-Targeted Maternal Antibodies Protect Neonates from Enteric Infection](/publications/microbiota-targeted-maternal-antibodies-protect-neonates-enteric-infection)”. Nature, 577, 7791, Pp. 543-48 - add\_circle do\_not\_disturb\_on Abstract Although maternal antibodies protect newborn babies from infection1,2, little is known about how protective antibodies are induced without prior pathogen exposure. Here we show that neonatal mice that lack the capacity to produce IgG are protected from... Deepshika Ramanan, Esen Sefik, Silvia Galvin-Pena, Meng Wu, Liang Yang, Zhen Yang, Aleksandar Kostic, Tatyana Golovkina, Dennis Kasper, Diane Mathis, and Christophe Benoist. 2020. “[An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint](/publications/immunologic-mode-multigenerational-transmission-governs-gut-treg-setpoint)”. Cell, 181, 6, Pp. 1276-90 Deepshika Ramanan, Esen Sefik, Silvia Galvin-Pena, Meng Wu, Liang Yang, Zhen Yang, Aleksandar Kostic, Tatyana Golovkina, Dennis Kasper, Diane Mathis, and Christophe Benoist. 2020. “[An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint](/publications/immunologic-mode-multigenerational-transmission-governs-gut-treg-setpoint)”. Cell, 181, 6, Pp. 1276-90 - add\_circle do\_not\_disturb\_on Abstract At the species level, immunity depends on the selection and transmission of protective components of the immune system. A microbe-induced population of RORg -expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. We uncovered... Meng Wu and Dennis Kasper. 2020. “[When Lab Mice Go Wild, Fungi Are in Play](/publications/when-lab-mice-go-wild-fungi-are-play)”. Cell Host Microbe, 27, 5, Pp. 687-88 Meng Wu and Dennis Kasper. 2020. “[When Lab Mice Go Wild, Fungi Are in Play](/publications/when-lab-mice-go-wild-fungi-are-play)”. Cell Host Microbe, 27, 5, Pp. 687-88 - add\_circle do\_not\_disturb\_on Abstract In this issue of Cell Host & Microbe, Yeung et al. (2020) and Lin et al. (2020) expose laboratory mice to a natural environment and use immune and microbiota characterization to show that fungi promote more human-like immunity. These studies will help... ### 2019 Giuseppe Stefanetti, Nihal Okan, Avner Fink, Erica Gardner, and Dennis Kasper. 2019. “[Glycoconjugate Vaccine Using a Genetically Modified O Antigen Induces Protective Antibodies to Francisella Tularensis](/publications/glycoconjugate-vaccine-using-genetically-modified-o-antigen-induces)”. Proc Natl Acad Sci U S A, 2019 Mar 14, [Epub ahead of print] . doi:10.1073/pnas.1900144116 Giuseppe Stefanetti, Nihal Okan, Avner Fink, Erica Gardner, and Dennis Kasper. 2019. “[Glycoconjugate Vaccine Using a Genetically Modified O Antigen Induces Protective Antibodies to Francisella Tularensis](/publications/glycoconjugate-vaccine-using-genetically-modified-o-antigen-induces)”. Proc Natl Acad Sci U S A, 2019 Mar 14, [Epub ahead of print] . doi:10.1073/pnas.1900144116 - add\_circle do\_not\_disturb\_on Abstract *Francisella tularensis* is the causative agent of tularemia, a category A bioterrorism agent. The lipopolysaccharide (LPS) O antigen (OAg) of has been considered for use in a glycoconjugate vaccine, but conjugate vaccines tested so far have failed to... Ximei Sun, Giuseppe Stefanetti, Francesco Berti, and Dennis Kasper. 2019. “[Polysaccharide Structure Dictates Mechanism of Adaptive Immune Response to Glycoconjugate Vaccines](/publications/polysaccharide-structure-dictates-mechanism-adaptive-immune-response)”. Proc Natl Acad Sci U S A, 116, 1, Pp. 193-98. doi:10.1073/pnas.1816401115 Ximei Sun, Giuseppe Stefanetti, Francesco Berti, and Dennis Kasper. 2019. “[Polysaccharide Structure Dictates Mechanism of Adaptive Immune Response to Glycoconjugate Vaccines](/publications/polysaccharide-structure-dictates-mechanism-adaptive-immune-response)”. Proc Natl Acad Sci U S A, 116, 1, Pp. 193-98. doi:10.1073/pnas.1816401115 - add\_circle do\_not\_disturb\_on Abstract Glycoconjugate vaccines are among the most effective interventions for preventing several serious infectious diseases. Covalent linkage of the bacterial capsular polysaccharide to a carrier protein provides CD4 T cells with epitopes that facilitate a... ### 2017 Neeraj Surana and Dennis Kasper. 2017. “[Moving Beyond Microbiome-Wide Associations to Causal Microbe Identification](/publications/moving-beyond-microbiome-wide-associations-causal-microbe-identification)”. Nature, 552, 7684, Pp. 244-47 Neeraj Surana and Dennis Kasper. 2017. “[Moving Beyond Microbiome-Wide Associations to Causal Microbe Identification](/publications/moving-beyond-microbiome-wide-associations-causal-microbe-identification)”. Nature, 552, 7684, Pp. 244-47 - add\_circle do\_not\_disturb\_on Abstract Microbiome-wide association studies have established that numerous diseases are associated with changes in the microbiota. These studies typically generate a long list of commensals implicated as biomarkers of disease, with no clear relevance to disease... Jason Hudak, David Alvarez, Ashwin Skelly, Ulrich Andrian, and Dennis Kasper. 2017. “[Illuminating Vital Surface Molecules of Symbionts in Health and Disease](/publications/illuminating-vital-surface-molecules-symbionts-health-and-disease)”. Nat Microbiol, 2, Pp. 17099 Jason Hudak, David Alvarez, Ashwin Skelly, Ulrich Andrian, and Dennis Kasper. 2017. “[Illuminating Vital Surface Molecules of Symbionts in Health and Disease](/publications/illuminating-vital-surface-molecules-symbionts-health-and-disease)”. Nat Microbiol, 2, Pp. 17099 - add\_circle do\_not\_disturb\_on Abstract The immunomodulatory surface molecules of commensal and pathogenic bacteria are critical to microorganisms' survival and the host's response1,2. Recent studies have highlighted the unique and important responses elicited by commensal-derived surface... Naama Geva-Zatorsky, Esen Sefik, Lindsay Kua, Lesley Pasman, Tze Guan Tan, Adriana Ortiz-Lopez, Tsering Bakto Yanortsang, Liang Yang, Ray Jupp, Diane Mathis, Christophe Benoist, and Dennis Kasper. 2017. “[Mining the Human Gut Microbiota for Immunomodulatory Organisms](/publications/mining-human-gut-microbiota-immunomodulatory-organisms)”. Cell, 168, 5, Pp. 928-943.e11 Naama Geva-Zatorsky, Esen Sefik, Lindsay Kua, Lesley Pasman, Tze Guan Tan, Adriana Ortiz-Lopez, Tsering Bakto Yanortsang, Liang Yang, Ray Jupp, Diane Mathis, Christophe Benoist, and Dennis Kasper. 2017. “[Mining the Human Gut Microbiota for Immunomodulatory Organisms](/publications/mining-human-gut-microbiota-immunomodulatory-organisms)”. Cell, 168, 5, Pp. 928-943.e11 - add\_circle do\_not\_disturb\_on Abstract Within the human gut reside diverse microbes coexisting with the host in a mutually advantageous relationship. Evidence has revealed the pivotal role of the gut microbiota in shaping the immune system. To date, only a few of these microbes have been shown... ### 2016 Francesca Gazzaniga and Dennis Kasper. 2016. “[Veggies and Intact Grains a Day Keep the Pathogens Away](/publications/veggies-and-intact-grains-day-keep-pathogens-away)”. Cell, 167, 5, Pp. 1161-62 Francesca Gazzaniga and Dennis Kasper. 2016. “[Veggies and Intact Grains a Day Keep the Pathogens Away](/publications/veggies-and-intact-grains-day-keep-pathogens-away)”. Cell, 167, 5, Pp. 1161-62 - add\_circle do\_not\_disturb\_on Abstract In this issue of Cell, Desai et al. compare how dietary fiber affects the gut microbiota and susceptibility to disease. They find that a fiber-free diet promotes mucus-degrading bacteria and susceptibility to Citrobacter rodentium infection. Thomas Gensollen, Shankar Iyer, Dennis Kasper, and Richard Blumberg. 2016. “[How Colonization by Microbiota in Early Life Shapes the Immune System](/publications/how-colonization-microbiota-early-life-shapes-immune-system)”. Science, 352, 6285, Pp. 539-44 Thomas Gensollen, Shankar Iyer, Dennis Kasper, and Richard Blumberg. 2016. “[How Colonization by Microbiota in Early Life Shapes the Immune System](/publications/how-colonization-microbiota-early-life-shapes-immune-system)”. Science, 352, 6285, Pp. 539-44 - add\_circle do\_not\_disturb\_on Abstract Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental... ### 2015 Naama Geva-Zatorsky, David Alvarez, Jason Hudak, Nicola Reading, Deniz Erturk-Hasdemir, Suryasarathi Dasgupta, Ulrich Andrian, and Dennis Kasper. 2015. “[In Vivo Imaging and Tracking of Host-Microbiota Interactions via Metabolic Labeling of Gut Anaerobic Bacteria](/publications/vivo-imaging-and-tracking-host-microbiota-interactions-metabolic-labeling-gut)”. Nat Med, 21, 9, Pp. 1091-100 Naama Geva-Zatorsky, David Alvarez, Jason Hudak, Nicola Reading, Deniz Erturk-Hasdemir, Suryasarathi Dasgupta, Ulrich Andrian, and Dennis Kasper. 2015. “[In Vivo Imaging and Tracking of Host-Microbiota Interactions via Metabolic Labeling of Gut Anaerobic Bacteria](/publications/vivo-imaging-and-tracking-host-microbiota-interactions-metabolic-labeling-gut)”. Nat Med, 21, 9, Pp. 1091-100 - add\_circle do\_not\_disturb\_on Abstract The intestine is densely populated by anaerobic commensal bacteria. These microorganisms shape immune system development, but understanding of host-commensal interactions is hampered by a lack of tools for studying the anaerobic intestinal environment. We... ### 2014 Neeraj Surana and Dennis Kasper. 2014. “[Deciphering the Tête-à-Tête Between the Microbiota and the Immune System](/publications/deciphering-t%C3%AAte-%C3%A0-t%C3%AAte-between-microbiota-and-immune-system)”. J Clin Invest, 124, 10, Pp. 4197-203 Neeraj Surana and Dennis Kasper. 2014. “[Deciphering the Tête-à-Tête Between the Microbiota and the Immune System](/publications/deciphering-t%C3%AAte-%C3%A0-t%C3%AAte-between-microbiota-and-immune-system)”. J Clin Invest, 124, 10, Pp. 4197-203 - add\_circle do\_not\_disturb\_on Abstract The past decade has witnessed an explosion in studies--both clinical and basic science--examining the relationship between the microbiota and human health, and it is now clear that the effects of commensal organisms are much broader than previously... Yan Wang, Kiel Telesford, Javier Ochoa-Repáraz, Sakhina Haque-Begum, Marc Christy, Eli Kasper, Li Wang, Yan Wu, Simon Robson, Dennis Kasper, and Lloyd Kasper. 2014. “[An Intestinal Commensal Symbiosis Factor Controls Neuroinflammation via TLR2-Mediated CD39 Signalling](/publications/intestinal-commensal-symbiosis-factor-controls-neuroinflammation-tlr2)”. Nat Commun, 5, Pp. 4432 Yan Wang, Kiel Telesford, Javier Ochoa-Repáraz, Sakhina Haque-Begum, Marc Christy, Eli Kasper, Li Wang, Yan Wu, Simon Robson, Dennis Kasper, and Lloyd Kasper. 2014. “[An Intestinal Commensal Symbiosis Factor Controls Neuroinflammation via TLR2-Mediated CD39 Signalling](/publications/intestinal-commensal-symbiosis-factor-controls-neuroinflammation-tlr2)”. Nat Commun, 5, Pp. 4432 - add\_circle do\_not\_disturb\_on Abstract The mammalian immune system constitutively senses vast quantities of commensal bacteria and their products through pattern recognition receptors, yet excessive immune reactivity is prevented under homeostasis. The intestinal microbiome can influence host... Suryasarathi Dasgupta, Deniz Erturk-Hasdemir, Javier Ochoa-Reparaz, Hans-Christian Reinecker, and Dennis Kasper. 2014. “[Plasmacytoid Dendritic Cells Mediate Anti-Inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms](/publications/plasmacytoid-dendritic-cells-mediate-anti-inflammatory-responses-gut)”. Cell Host Microbe, 15, 4, Pp. 413-23 Suryasarathi Dasgupta, Deniz Erturk-Hasdemir, Javier Ochoa-Reparaz, Hans-Christian Reinecker, and Dennis Kasper. 2014. “[Plasmacytoid Dendritic Cells Mediate Anti-Inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms](/publications/plasmacytoid-dendritic-cells-mediate-anti-inflammatory-responses-gut)”. Cell Host Microbe, 15, 4, Pp. 413-23 - add\_circle do\_not\_disturb\_on Abstract Polysaccharide A (PSA), the archetypical immunomodulatory molecule of the gut commensal Bacteroides fragilis, induces regulatory T cells to secrete the anti-inflammatory cytokine interleukin-10 (IL-10). The cellular mediators of PSA's immunomodulatory... Dingding An, Sungwhan Oh, Torsten Olszak, Joana Neves, Fikri Avci, Deniz Erturk-Hasdemir, Xi Lu, Sebastian Zeissig, Richard Blumberg, and Dennis Kasper. 2014. “[Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells](/publications/sphingolipids-symbiotic-microbe-regulate-homeostasis-host-intestinal-natural)”. Cell, 156, 1-2, Pp. 123-33 Dingding An, Sungwhan Oh, Torsten Olszak, Joana Neves, Fikri Avci, Deniz Erturk-Hasdemir, Xi Lu, Sebastian Zeissig, Richard Blumberg, and Dennis Kasper. 2014. “[Sphingolipids from a Symbiotic Microbe Regulate Homeostasis of Host Intestinal Natural Killer T Cells](/publications/sphingolipids-symbiotic-microbe-regulate-homeostasis-host-intestinal-natural)”. Cell, 156, 1-2, Pp. 123-33 - add\_circle do\_not\_disturb\_on Abstract Coevolution of beneficial microorganisms with the mammalian intestine fundamentally shapes mammalian physiology. Here, we report that the intestinal microbe Bacteroides fragilis modifies the homeostasis of host invariant natural killer T (iNKT) cells by... ### 2013 Nihal Okan and Dennis Kasper. 2013. “[The Atypical Lipopolysaccharide of Francisella](/publications/atypical-lipopolysaccharide-francisella)”. Carbohydr Res, 378, Pp. 79-83 Nihal Okan and Dennis Kasper. 2013. “[The Atypical Lipopolysaccharide of Francisella](/publications/atypical-lipopolysaccharide-francisella)”. Carbohydr Res, 378, Pp. 79-83 - add\_circle do\_not\_disturb\_on Abstract Bacterial lipopolysaccharides (LPSs) are ubiquitous molecules that are prominent components of the outer membranes of most gram-negative bacteria. Genetic and structural characterizations of Francisella LPS have revealed substantial differences when... Deniz Erturk-Hasdemir and Dennis Kasper. 2013. “[Resident Commensals Shaping Immunity](/publications/resident-commensals-shaping-immunity)”. Curr Opin Immunol, 25, 4, Pp. 450-5 Deniz Erturk-Hasdemir and Dennis Kasper. 2013. “[Resident Commensals Shaping Immunity](/publications/resident-commensals-shaping-immunity)”. Curr Opin Immunol, 25, 4, Pp. 450-5 - add\_circle do\_not\_disturb\_on Abstract All animals coexist with myriad commensal microorganisms in a symbiotic relationship that plays a key role in health and disease. Continuous commensal-host interactions profoundly affect the development and regulation of the host's immune system. The... - Previous page chevron\_left - [1](?page=0 "Current page") - [2](?page=1 "Go to page 2") - [3](?page=2 "Go to page 3") - [ Next page chevron\_right ](?page=1 "Go to next page")