# Kasper Laboratory ![Dennis Kasper](/sites/g/files/omnuum3561/files/styles/hwp_21_9__1920x825/public/kasperlab/files/dennis-kasper.jpg?itok=FJltm4no) ## What We Do The focus of the Kasper laboratory is on the centrality of the microbiome in immune system development, maturation, and regulation. The laboratory’s research defines the phylogenetic diversity, immune mechanisms, and immunomodulatory therapeutic potential of bacteria and bacterial molecules in autoimmune and infectious diseases. We also investigate the chemistry and immunology of bacterial polysaccharides and lipids, gaining fundamental insights into their role in pathogenesis, as protective vaccine antigens, and as critical modulators of mucosal and systemic immunity. ## Selected Recent Publications Download 3 citations download- [BibTeX](/bibcite/export?pager_style=no_pager&number_of_items=3&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1502661&content_filter%5B1%5D=1502656&content_filter%5B2%5D=1364630&content_filter%5B3%5D=1364629&&format=bibtex) - [EndNote X3 XML](/bibcite/export?pager_style=no_pager&number_of_items=3&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1502661&content_filter%5B1%5D=1502656&content_filter%5B2%5D=1364630&content_filter%5B3%5D=1364629&&format=endnote8) - [EndNote 7 XML](/bibcite/export?pager_style=no_pager&number_of_items=3&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1502661&content_filter%5B1%5D=1502656&content_filter%5B2%5D=1364630&content_filter%5B3%5D=1364629&&format=endnote7) - [Endnote tagged](/bibcite/export?pager_style=no_pager&number_of_items=3&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1502661&content_filter%5B1%5D=1502656&content_filter%5B2%5D=1364630&content_filter%5B3%5D=1364629&&format=tagged) - [Marc](/bibcite/export?pager_style=no_pager&number_of_items=3&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1502661&content_filter%5B1%5D=1502656&content_filter%5B2%5D=1364630&content_filter%5B3%5D=1364629&&format=marc) - [PubMedId](/bibcite/export?pager_style=no_pager&number_of_items=3&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1502661&content_filter%5B1%5D=1502656&content_filter%5B2%5D=1364630&content_filter%5B3%5D=1364629&&format=pubmed_id) - [RIS](/bibcite/export?pager_style=no_pager&number_of_items=3&sort_field=bibcite_year--desc&&content_filter%5B0%5D=1502661&content_filter%5B1%5D=1502656&content_filter%5B2%5D=1364630&content_filter%5B3%5D=1364629&&format=ris) ### 2024 Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C Macbeth, Elyza A Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M Chiu, Jeffrey R Moffitt, Ansel Hsiao, John J Mekalanos, Christophe Benoist, and Dennis L Kasper. 2024. “[Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals.](/publication/gut-complement-induced-microbiota-combats-pathogens-and-spares-commensals)”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036 Meng Wu, Wen Zheng, Xinyang Song, Bin Bao, Yuanyou Wang, Deepshika Ramanan, Daping Yang, Rui Liu, John C Macbeth, Elyza A Do, Warrison A Andrade, Tiandi Yang, Hyoung-Soo Cho, Francesca S Gazzaniga, Marit Ilves, Daniela Coronado, Charlotte Thompson, Saiyu Hang, Isaac M Chiu, Jeffrey R Moffitt, Ansel Hsiao, John J Mekalanos, Christophe Benoist, and Dennis L Kasper. 2024. “[Gut Complement Induced by the Microbiota Combats Pathogens and Spares Commensals.](/publication/gut-complement-induced-microbiota-combats-pathogens-and-spares-commensals)”. Cell, 187, 4, Pp. 897-913.e18. doi:10.1016/j.cell.2023.12.036 - add\_circle do\_not\_disturb\_on Abstract Canonically, the complement system is known for its rapid response to remove microbes in the bloodstream. However, relatively little is known about a functioning complement system on intestinal mucosal surfaces. Herein, we report the local synthesis of... ### 2023 2023. “[Targeting PD-L2-RGMG Overcomes Microbiome-Related Immunotherapy Resistance.](/publications/targeting-pd-l2-rgmg-overcomes-microbiome-related-immunotherapy-resistance)”. Nature, 617, Pp. 377-85 2023. “[Targeting PD-L2-RGMG Overcomes Microbiome-Related Immunotherapy Resistance.](/publications/targeting-pd-l2-rgmg-overcomes-microbiome-related-immunotherapy-resistance)”. Nature, 617, Pp. 377-85 - add\_circle do\_not\_disturb\_on Abstract - [ descriptionPublisher's Version](https://doi.org/10.1038/s41586-023-06026-3) - [ picture\_as\_pdftargeting\_pd-l2-rgmb\_over...](/sites/g/files/omnuum3561/files/kasperlab/files/targeting_pd-l2-rgmb_overcomes_microbiome-related_immunotherapy_resistance_-_s41586-023-06026-3.pdf.pdf) - [ descriptionPublisher's Version](https://doi.org/10.1038/s41586-023-06026-3) - [ picture\_as\_pdftargeting\_pd-l2-rgmb\_over...](/sites/g/files/omnuum3561/files/kasperlab/files/targeting_pd-l2-rgmb_overcomes_microbiome-related_immunotherapy_resistance_-_s41586-023-06026-3.pdf.pdf) ### 2020 Deepshika Ramanan, Esen Sefik, Silvia Galvin-Pena, Meng Wu, Liang Yang, Zhen Yang, Aleksandar Kostic, Tatyana Golovkina, Dennis Kasper, Diane Mathis, and Christophe Benoist. 2020. “[An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint](/publications/immunologic-mode-multigenerational-transmission-governs-gut-treg-setpoint)”. Cell, 181, 6, Pp. 1276-90 Deepshika Ramanan, Esen Sefik, Silvia Galvin-Pena, Meng Wu, Liang Yang, Zhen Yang, Aleksandar Kostic, Tatyana Golovkina, Dennis Kasper, Diane Mathis, and Christophe Benoist. 2020. “[An Immunologic Mode of Multigenerational Transmission Governs a Gut Treg Setpoint](/publications/immunologic-mode-multigenerational-transmission-governs-gut-treg-setpoint)”. Cell, 181, 6, Pp. 1276-90 - add\_circle do\_not\_disturb\_on Abstract At the species level, immunity depends on the selection and transmission of protective components of the immune system. A microbe-induced population of RORg -expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. We uncovered... [ More arrow\_circle\_right ](/kasper-publications)